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Cancer of the Small Bowel

Cancer of the small bowel

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Cancer of the small bowel is less common than cancer of the large bowel. 52,000 people die from large bowel cancer per year compared to only about 1,100 from cancer of the small bowel. About 6,960 people will be diagnosed with the disease during this year and the rate is the same in women as in men.

The Small Intestine

The small bowel is also called the small intestine. It is a 15-30 foot long piece of intestine that attaches the stomach to the large colon. It is so long that one would expect it to have a greater chance of developing cancer, but as noted above, cancer of the small bowel is not very common.

The small bowel consists of three parts—the duodenum, the jejunum and the ileum that do similar but distinctly different jobs for digestion. For the most part, the job of the small bowel is to break down food and absorb it into the digestive system. Vitamins, minerals and food nutrients are all absorbed into the system by means of the small bowel.

Cause

Cancer of the small bowel has no known cause. There are some other diseases a person might have that would predispose the individual to getting small bowel cancer. These include inflammatory diseases like Crohn’s disease, Peutz-Jegher’s syndrome, intestinal polyposis syndrome and celiac sprue. If you have a decreased level of immune function, such as having AIDS, you are at risk for developing cancer of the small bowel.

The condition also seems to be related to alcoholism and heavy alcohol use as well as eating lots of sugar. Also, men who smoke cigarettes have a higher risk of cancer of the bowel as well as those who eat a lot of fired bacon, barbecued meats or fish and ham. These contain a lot of heterocyclic amines that can cause cancer of the small bowel.

Types of Small Bowel Cancer

There are basically four types of cancer of the small bowel:

  • Adenocarcinoma—this primarily begins in the duodenum and affects the lining of the intestinal wall. Males get this condition more often and get it around the ages 50-70. Crohn’s disease patients may get it at a younger age.
  • Sarcoma—this starts in the smooth muscle of the bowel and is most common in the ileum.
  • Carcinoid tumor—this occurs in the hormone-producing cells and generally occurs in the ileum or in the appendix. It can occur as a cancer of the small bowel in those as early as the 20’s.
  • Lymphoma—this tends to occur in the lymph tissue around the small bowel and often occurs in the jejunum. It is usually non-Hodgkin’s lymphoma and occurs more often in those who were transplant patients or AIDS patients.

Symptoms

Some cancers of the small bowel are actually metastatic from other body areas. Rare types of small bowel cancer include leimyomas, fibromas or lipomas.

Symptoms of small bowel cancer are nonspecific and include cramps, abdominal pain, weight loss, diarrhea, black stools from digested blood, blood in the stools or jaundice. Rarely, bowel obstruction can occur from this type of cancer of the small bowel. This causes abdominal distention and severe abdominal pain.

The condition is diagnosed using stool samples for blood, colonoscopy to examine the duodenum and a CT scan of the abdomen or MRI scan of the abdomen to look for cancer of the small bowel. Both the CT scan and the MRI scan can pick up liver involvement in cancer. Barium swallow tests allow barium to pass through the intestinal tract and can pick up polypoid cancers. If a cancerous or suspicious lesion is found, then surgery is done to biopsy and likely remove the cancer of the small bowel.

Stages

There are four stages of cancer of the small bowel:

  • Stage I is localized cancer not spread past the bowel wall.
  • Stage II involves cancer that has spread outside of the wall of the bowel.
  • Stage III cancer means lymph nodes have become involved.
  • Stage IV means that other body areas, such as the liver or the lung have become involved with cancer.

Treatment

The treatment varies according to the type of cancer but basically starts with surgery to remove the bulk of the tumor. If the tumor is removed well, about 40-60 percent of people survive past 5 years. Sometimes parts of the stomach, pancreas and a large part of the small bowel need removal. Radiation therapy can be used to get rid of any residual tumor. Chemotherapy is also used to get rid of stray cells. More recently, immune stimulating drugs have been developed that help the body fight off the cancer on its own.

Written by Christine Traxler

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